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          Cleaved-Tumstatin (P1426) rabbit pAb
          
                    
          一鍵復(fù)制產(chǎn)品信息
          
                    ES1056
                    
          
                        
                        
          
                            
          
                                規(guī)格：
                                價(jià)格：
                            
          
                                                        
          
                                50μL
                                ￥1280.00
                            
          
                                                        
          
                                100μL
                                ￥1980.00
                            
          
                                                    
          
                    
          
                    
                
          
            
          
        
          

                
          
            
          
                
          Overview
                    
          
                
          
                    
          
                        
          
                            
          
                                
          
                                    
          
                                        Product name:
                                        Cleaved-Tumstatin (P1426) rabbit pAb
                                    
          
                                                                            
          
                                            Reactivity:
                                            Human;Monkey
                                        
          
                                                                                
          
                                            Alternative Names:
                                            COL4A3; Collagen alpha-3(IV) chain; Goodpasture antigen
                                        
          
                                                                                
          
                                           Source:
                                           Rabbit
                                           
                                        
          
                                                                                
          
                                           Dilutions:
                                           Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
                                           
                                        
          
                                                                                
          
                                           Immunogen:
                                           The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:1407-1456
                                           
                                        
          
                                                                                
          
                                           Storage:
                                           -20°C/1 year
                                           
                                        
          
                                                                                
          
                                           Clonality:
                                           Polyclonal
                                           
                                        
          
                                                                                
          
                                           Isotype:
                                           IgG
                                           
                                        
          
                                                                                
          
                                           Concentration:
                                           1 mg/ml
                                           
                                        
          
                                                                                
          
                                           Observed Band:
                                           27kD
                                           
                                        
          
                                                                                
          
                                           GeneID:
                                           1285
                                           
                                        
          
                                                                                
          
                                           Human Swiss-Prot No:
                                           Q01955
                                           
                                        
          
                                                                                
          
                                           Cellular localization:
                                           Secreted, extracellular space, extracellular matrix, basement membrane. Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL). .
                                           
                                        
          
                                                                                
          
                                           Background:
                                           Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r
                                           
                                        
          
                                                                        
          
                            
          
                                                    
          
                    
          
                
          
            
          
                        
                    
          
    
          
    




          
    
          
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